Selecting the right drug candidates and formulating them for success requires more than isolated data points—it demands a holistic understanding of how biomolecules behave and interact with each other. In this webinar, we will demonstrate how microcalorimetry, thermal analysis, and rheology deliver complementary insights into the properties that matter most: binding energetics, molecular and thermal stability, phase behavior, moisture content, and flow performance. By connecting heat, weight, and flow measurements, researchers can rapidly differentiate promising candidates, de-risk formulations, and resolve common development challenges before they reach late-stage testing.

Join us to see how integrating these techniques into your workflow can accelerate the path to a high-quality biopharmaceutical product by:

• shortening development timelines
• improving formulation robustness
• increasing confidence in critical go/no go decisions

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Viviana Costa, PhD
Applications Scientist
Waters Materials Sciences (formerly Waters TA Instruments)

Viviana Costa earned her master’s degree in chemical engineering from the University of Coimbra, Portugal and her Ph.D. in Chemistry from Texas Christian University, Fort Worth, Texas. Dr. Costa joined TA instruments in 2023 as an Applications Scientist, based in Lindon, Utah. She supports the microcalorimetry product line and related applications.

In this second part of the webinar series on rheometric applications, we explore advanced applications of Optimally Windowed Chirps (or OWCh) to characterize complex material systems, including aging thixotropic systems such as clay dispersions. We describe how user control of the initial phase and the frequency slew rate of the chirp, which is a new approach to rapidly obtain frequency dependent material behavior, can be leveraged to improve data quality for very short chirps or highly viscoelastic samples.

We also introduce a recent Thermally Optimized Ramped Chirp (TORCh) protocol, which applies a user‑controlled heating rate to the sample while repeatedly applying windowed chirp pulses. This approach enables rapid construction of time–temperature master curves for polymer samples over a wide range of reduced frequencies.

With these tools, rheologists can design chirp‑based testing techniques and quality control protocols that significantly improve sample throughput. Compared with other approaches, the chirp-based ones increase data quality and density—supporting future data‑driven scientific machine learning (SciML) applications.

What you’ll learn:

• Discover how optimally‑windowed exponential chirps (OWCh) deliver rapid, broadband viscoelastic spectra for mutating materials in seconds.
• Learn how to minimize spectral leakage, tune chirp parameters, and implement protocols in MATLAB or instrument firmware for high‑quality, time‑resolved data.
• Learn how to use Thermally Optimized Ramped Chirp (TORCh) protocols to produce time-temperature superposition master curves in significantly less time.

Gareth McKinley
Professor of Mechanical Engineering • MIT

Gareth H. McKinley is a renowned mechanical engineer and professor at the Massachusetts Institute of Technology (MIT), where he serves as the School of Engineering Professor of Teaching Innovation and Professor of Mechanical Engineering.

McKinley is internationally recognized for his expertise in fluid dynamics and rheology—the study of how complex materials flow and deform. His research explores non-Newtonian fluids, microfluidics, hydrogels, and advanced materials, with applications ranging from industrial processes to biotechnology. His work has led to important advances in understanding phenomena such as bubble formation in liquids and the behavior of viscoelastic materials, as well as practical innovations like techniques for harvesting drinking water from fog in arid environments.

He earned his Ph.D. from MIT in 1991 after completing a B.A. and M.Eng. at the University of Cambridge. Over his career, McKinley has published more than 275 scientific papers and has played a significant role in shaping the field of rheology.

His achievements have been widely honored. He is a Fellow of the Royal Society and the American Physical Society and a member of the U.S. National Academy of Engineering. He has also received major awards such as the Bingham Medal and the Gold Medal of the British Society of Rheology.

In addition to his research, McKinley has held several leadership roles at MIT and is known for his dedication to teaching and mentoring, influencing the next generation of engineers and scientists.

In this two‑part webinar, we illustrate how modern broadband rheometric techniques can be used to measure the material functions of what may broadly be referred to as mutating materials (or changing materials), with rheological properties that are both time‑ and frequency‑dependent.

Numerous approaches have been proposed in the past for developing time‑resolved rheometric protocols capable of providing both time‑and frequency‑resolved measurements on aging, curing, or crosslinking gel systems. These include multi‑wave techniques, random/white noise sequences, short‑time Fourier transforms, and repeated step‑strain pulses.

In Part I of this webinar series, we show how a common audio signal processing sequence—the exponential chirp—can be adapted to rheometry, and explain why it offers several benefits, including a frequency‑independent amplitude and a continuously varying phase. This enables the linear viscoelastic properties, such as G′ and G″, of a time‑evolving material (e.g., a thermally or chemically crosslinking gel) to be rapidly determined over several decades in frequency within just a few minutes.

However, closer investigation of data on model polymer networks shows that measurement precision is compromised at the highest and lowest test frequencies due to “leakage” of material information into side lobes of the signal’s power spectrum. Taking inspiration from chirp sequences used by bats and dolphins in echolocation, we explain how these inaccuracies can be mitigated by adding a carefully chosen windowing function or envelope to the chirp.

The resulting waveforms can be readily encoded in MATLAB or implemented directly through instrument firmware such as Fast Frequency Chirps, and then used to impose optimal deformations in controlled‑strain or controlled‑stress rheometers. Numerical computations and experimental measurements show that the error magnitude can be reduced exponentially with correct selection of window parameters and careful signal conditioning.

We first demonstrate basic applications of the technique using a semi‑dilute entangled polymer solution, a wormlike micellar fluid, and a time‑evolving crosslinked biopolymer gel. These examples show that the resulting Optimally Windowed Chirp (OWCh) technique can rapidly and accurately extract the entire linear viscoelastic spectrum of a time‑evolving complex material in less than 15 seconds (the time typically required to obtain the complex modulus at a single low frequency).

What you’ll learn:

• Discover how optimally‑windowed exponential chirps (OWCh) deliver rapid, broadband viscoelastic spectra for mutating materials in seconds.
• Learn how to minimize spectral leakage, tune chirp parameters, and implement protocols in MATLAB or instrument firmware for high‑quality, time‑resolved data.

Gareth McKinley
Professor of Mechanical Engineering • MIT

Gareth H. McKinley is a renowned mechanical engineer and professor at the Massachusetts Institute of Technology (MIT), where he serves as the School of Engineering Professor of Teaching Innovation and Professor of Mechanical Engineering.

McKinley is internationally recognized for his expertise in fluid dynamics and rheology—the study of how complex materials flow and deform. His research explores non-Newtonian fluids, microfluidics, hydrogels, and advanced materials, with applications ranging from industrial processes to biotechnology. His work has led to important advances in understanding phenomena such as bubble formation in liquids and the behavior of viscoelastic materials, as well as practical innovations like techniques for harvesting drinking water from fog in arid environments.

He earned his Ph.D. from MIT in 1991 after completing a B.A. and M.Eng. at the University of Cambridge. Over his career, McKinley has published more than 275 scientific papers and has played a significant role in shaping the field of rheology.

His achievements have been widely honored. He is a Fellow of the Royal Society and the American Physical Society and a member of the U.S. National Academy of Engineering. He has also received major awards such as the Bingham Medal and the Gold Medal of the British Society of Rheology.

In addition to his research, McKinley has held several leadership roles at MIT and is known for his dedication to teaching and mentoring, influencing the next generation of engineers and scientists.