Webinar

Selecting Candidates & Optimizing Drug Formulations – Leveraging Heat, Weight, and Flow

网络研讨会

TA仪器向您推荐RS-DSC：筛选高浓度生物药热稳定性的免稀释方法

Overview

Researchers are working tirelessly to understand the basic chemical details of viral pathogenesis, viral protein structures, and identifying therapeutics to disrupt and prevent disease. There are different modes of therapies evolving that include small-molecule antiviral drugs, mRNA, and protein-based vaccines. Microcalorimetry is one powerful tool for the development and characterization of the mechanism of action for these therapies. Isothermal Titration Calorimetry (ITC), Nano Differential Scanning Calorimetry (nanoDSC), and Isothermal Calorimetry (IC) are label-free and immobilization free analytic methods used for critical thermodynamic measurements. The focus of this webinar will be on utilizing these techniques to study molecular binding, biomolecular thermostability, long-term stability and their use in quality control; each an essential step in the development of a successful drug/vaccine candidate.

About the Speaker

Dr. Calliste Reiling is an Application Engineer at TA Instruments, currently supporting the microcalorimetry product line. She received her Ph.D. in Pharmaceutical Sciences from University of Nebraska Medical Center, where she investigated the thermodynamic properties of a variety of DNA and RNA secondary structures, their targeting reactions with partially complementary strands and the importance of water and ions. She also received her master’s from University of Nebraska Medical Center in Biochemistry and Molecular Biology with research centered around the structural biology of regulatory proteins involved in the endocytic pathway and their binding interactions. Calliste joined TA Instruments in 2018. Her key responsibilities at TA Instruments are customer support, consultation, and teaching microcalorimetry training courses.

Overview

In order to meet growing market demands for power storage, Lithium ion and new battery chemistries demand higher energy density, longer cycle life, calendar life, and better safety to a lower cost. Isothermal microcalorimetry is a highly sensitive, non-destructive and non-specific tool to characterize these critical performance criteria. Learn how this method provides:

• Sensitivity for quality control of batteries for critical products such as pacemakers and other medical devices
• Non-destructive measurements of discharge and charging conditions while also allowing further analysis to be made by other methods on the same specimen
• Non-specificity to measure all processes that go on in the battery with no need to predefine the property that should be measured
• Capacity to connect to a battery cycler and/or a voltmeter for the evaluation of the voltage dependences on battery performance.

Calorimetric tests can be performed on the battery itself, on model systems in pouch cells, and on combinations of components or single components. The modular isothermal multichannel microcalorimetric system, TAM, makes it possible to obtain these critical insights in a manner that is tailored to batteries or battery components of many sizes, shapes, configurations, and use or storage conditions.

About the Speaker

Malin Suurkuusk is the Isothermal Calorimetry Product Manager / Application Specialist at TA Instruments. She holds a Masters of Science Degree in Biochemistry from Stockholm University, and a PhD from the University of Lund where she studied in the lab of Prof. Ingemar Wadsö. She has worked extensively with Differential Scanning Calorimetry and Isothermal Titration Calorimetry, as well as other biophysical methods. Her early work in microcalorimetry instrument development included responsibilities in product management, applications lab management and marketing at Thermometric in Sweden. She is considered the world’s leading expert on the TAM isothermal instruments with numerous microcalorimetry publications. In October of 2014 she was recognized for her contributions to the field of microcalorimetry, and featured as a Biophysicist in Profile by the Biophysical Society.

Overview

In order to meet growing market demands for power storage, Lithium ion and new battery chemistries demand higher energy density, longer cycle life, calendar life, and better safety to a lower cost. Isothermal microcalorimetry is a highly sensitive, non-destructive and non-specific tool to characterize these critical performance criteria. Learn how this method provides:

• Sensitivity for quality control of batteries for critical products such as pacemakers and other medical devices
• Non-destructive measurements of discharge and charging conditions while also allowing further analysis to be made by other methods on the same specimen
• Non-specificity to measure all processes that go on in the battery with no need to predefine the property that should be measured
• Capacity to connect to a battery cycler and/or a voltmeter for the evaluation of the voltage dependences on battery performance.

Calorimetric tests can be performed on the battery itself, on model systems in pouch cells, and on combinations of components or single components. The modular isothermal multichannel microcalorimetric system, TAM, makes it possible to obtain these critical insights in a manner that is tailored to batteries or battery components of many sizes, shapes, configurations, and use or storage conditions.

About the Speaker

Malin Suurkuusk is the Isothermal Calorimetry Product Manager / Application Specialist at TA Instruments. She holds a Masters of Science Degree in Biochemistry from Stockholm University, and a PhD from the University of Lund where she studied in the lab of Prof. Ingemar Wadsö. She has worked extensively with Differential Scanning Calorimetry and Isothermal Titration Calorimetry, as well as other biophysical methods. Her early work in microcalorimetry instrument development included responsibilities in product management, applications lab management and marketing at Thermometric in Sweden. She is considered the world’s leading expert on the TAM isothermal instruments with numerous microcalorimetry publications. In October of 2014 she was recognized for her contributions to the field of microcalorimetry, and featured as a Biophysicist in Profile by the Biophysical Society.

Overview

Researchers are working tirelessly to understand the basic chemical details of viral pathogenesis, viral protein structures, and identifying therapeutics to disrupt and prevent disease. There are different modes of therapies evolving that include small-molecule antiviral drugs, mRNA, and protein-based vaccines. Microcalorimetry is one powerful tool for the development and characterization of the mechanism of action for these therapies. Isothermal Titration Calorimetry (ITC), Nano Differential Scanning Calorimetry (nanoDSC), and Isothermal Calorimetry (IC) are label-free and immobilization free analytic methods used for critical thermodynamic measurements. The focus of this webinar will be on utilizing these techniques to study molecular binding, biomolecular thermostability, long-term stability and their use in quality control; each an essential step in the development of a successful drug/vaccine candidate.

About the Speaker

Dr. Calliste Reiling is an Application Engineer at TA Instruments, currently supporting the microcalorimetry product line. She received her Ph.D. in Pharmaceutical Sciences from University of Nebraska Medical Center, where she investigated the thermodynamic properties of a variety of DNA and RNA secondary structures, their targeting reactions with partially complementary strands and the importance of water and ions. She also received her master’s from University of Nebraska Medical Center in Biochemistry and Molecular Biology with research centered around the structural biology of regulatory proteins involved in the endocytic pathway and their binding interactions. Calliste joined TA Instruments in 2018. Her key responsibilities at TA Instruments are customer support, consultation, and teaching microcalorimetry training courses.