Dile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability This webinar is focused on enthalpy screening, a new and recently published ITC technique that is showing promise for rapidly and accurately characterizing the binding enthalpy of new drugs or biotherapeutics. Rapid and accurate characterization of biopharmaceuticals is essential for the early selection of…
The new TAM IV is the world’s most sensitive, stable, and flexible microcalorimeter system. It is completely modular and combines the highest heat flow sensitivity with unmatched long-term temperature stability to measure processes that are undetectable by other techniques.
In this TA Webinar, Professor Nand Kishore discusses how to best discover and interpret protein folding, ligand binding, aggregation and molecular partitioning in self assemblies. Tribology complements rheology, providing information on solid-solid interactions that adds insight to the bulk fluid measurements of rheology. Tribology is especially concerned with quantifying the coefficient of friction as a…
Detecting and monitoring biological processes with isothermal calorimetry has been shown to be an accurate analytical technique and is proportional to the rate at which a given chemical or physical process takes place. The development of modern isothermal microcalorimeters has made the measurements of sub-microwatt amounts of heat flow possible accurate and reproducible. As a…
In this TA Instruments sponsored webinar, Dr. Nichola Garbett discusses the emerging technique of using high sensitivity DSC analysis of blood plasma for plasma proteome research, and as a clinical diagnostic tool.
High affinity and selectivity are two essential properties of drug molecules. Since the binding affinity is determined by the sum of enthalpic and entropic contributions, extremely high affinity necessitates optimization of both contributions to binding. An efficient approach requires accurate prediction of the contributions of specific interactions and chemical functionalities to the enthalpy and entropy…
