How to Accelerate Thermal Stability Testing for High-Concentration Drugs

微量量热法, 生物制药

The stability of high-concentration drugs can change under storage conditions, but until now, thermal testing in the lab using traditional calorimetry methods has been time-consuming and challenging. The new TA Instruments RS-DSC fills a critical antibody formulation development gap by allowing for high-throughput short-term thermal stability testing at formulation strength concentrations. In this blog, we explore why that’s essential.

Unlocking Stability: The Crucial Role of Thermal Analysis in Lyophilization Temperature Optimization

微量量热法, 生物制药

The method of drug delivery significantly influences the final stages of the manufacturing process. Currently, lyophilization—a widely adopted technique—enables drug developers to stabilize formulations and therapeutic molecules using a validated commercial approach. In this process, precise control of pressure and temperature within a lyophilizer facilitates the removal of liquids from formulations containing thermally sensitive or hydrolytically unstable active pharmaceutical ingredients or formulation components.

微量热法历史

微量量热法, 生物制药

在整个 18 世纪，许多科学家都在质疑热的本质。Isaac Newton 认为，热量通过粒子的振动进行传递，而 Robert Hooke 则认为，热量是物体的一种属性，由其各部分的运动产生。 不过，在热测量历史中，广为人知的首位贡献者是苏格兰医生兼化学家 Joseph Black。 1761 年，他通过精确测量发现，对处于熔点的冰或处于沸点的水加热不会导致温度变化。 他的观察使他成为第一个区分温度和热量的科学家，标志着热力学的开端。

经济且高效地升级实验室仪器的 4 种方法

Polymers, Thermal Analysis, 制药, 医疗器械, 复合材料, 微量量热法, 机械测试, 流变, 涂料, 生物制药, 电子材料及产品, 电池及电池材料

技术的发展日新月异。无论您是升级旧设备还是为您的工作台添加新技术，使用尖端仪器都一定会提高您实验室的效率和成果。新型仪器可提供更可靠的数据和更先进的功能，这对于始终立足于材料创新前沿而言至关重要。