INTRODUCTION Pressure Perturbation Calorimetry (PPC) is a technique for determination of thermal and volumetric properties of macromolecules. These properties include the partial molar thermal cubic expansion coefficient (ᾱ, Equation 1, [1]) and the relative partial molar volume (∆V/V, Equation 2, [2]) of the macromolecule as functions of temperature. These parameters are associated with hydration of the macromolecule [3, 4]. The method consists of measuring the heat effect, ΔQ, from applying a pressure change, Δp, to a solution of the macromolecule. ᾱ and ∆V/V are then calculated by the following equations
Keywords: MCAPN-2010-03