Experimental Design for the Determination of Kinetic Parameters Using the Multiple Injection Method (MIM) with Isothermal Titration Calorimetry (ITC)

<< View all Application Notes ABSTRACT: Thermal stability signatures of biological fluids, comprised of a complex milieu of protein can be measured using differential scanning calorimetry (DSC). The DSC is a powerful tool in monitoring changes in the protein equilibrium that is perturbed by disease or cancer through amplification, modification, or multiple interactions of proteins…

Details

The Impact of Electrolyte Additives in Lithium-ion Batteries Determined Using Isothermal Microcalorimetry

<< View all Application Notes ABSTRACT Isothermal microcalorimetry is a simple method of determining the effect an electrolyte additive or additive combination has on the parasitic reactions occurring in a lithium-ion battery as a function of state of charge. In this study, high resolution isothermal microcalorimetry using a TAM III equipped with 12 microcalorimeters is…

Details

Multistep Reaction Model for Ignition of Nanocomposite Thermites

<< View all Application Notes ABSTRACT Nanocomposite thermites include a reactive metal, in most cases aluminum, mixed on the nano-scale with a metal oxide. The nano-scale mixing achieved by ball-milling produces a highly developed and unusual interface area between reactive components. The high interface area assures a high reaction rate, attractive for propellants, explosives, and…

Details

Pressure Perturbation Calorimetry: Data Collection and Fitting

<< View all Application Notes INTRODUCTION Pressure Perturbation Calorimetry (PPC) is a technique for determination of thermal and volumetric properties of macromolecules. These properties include the partial molar thermal cubic expansion coefficient (ᾱ, Equation 1, [1]) and the relative partial molar volume (∆V/V, Equation 2, [2]) of the macromolecule as functions of temperature. These parameters…

Details

Scanning Complex Biological Samples

<< View all Application Notes ABSTRACT: Thermal stability signatures of biological fluids, comprised of a complex milieu of protein can be measured using differential scanning calorimetry (DSC). The DSC is a powerful tool in monitoring changes in the protein equilibrium that is perturbed by disease or cancer through amplification, modification, or multiple interactions of proteins…

Details

Characterizing Binding Interactions by ITC

<< View all Application Notes INTRODUCTION All biochemical reactions involve recognition, binding and the formation of non-covalent complexes. Since the characterization of binding events is central to understanding any physiological process at the molecular level, biochemical and biomedical research requires methodologies for precisely analyzing binding reactions. Isothermal titration calorimetry (lTC) is rapidly becoming the method…

Details

Analytical Rheology

Analytical Rheology Analytic rheology is the subject of determining the microstructure of a material from measurements of its viscoelastic response. Analytic rheology is an extension of analytic chemistry in much the same sense as other analytic methods predicated on flow properties. Intrinsic viscosity is an example of an analytical technique that falls into this category.…

Details